Does Ash marry Misty?
Many fans take this as proof that Ash and Misty ended up together, and that Ash bequeathed his Pikachu onto his daughter. This would most likely have meant the end of the Pokémon anime as we know it today.
Why did Serena leave Ash?
In Till We Compete Again!, Serena officially left the group to follow Palermo’s advice and travel the Hoenn region. At the airport, Serena told Ash she vowed to become better, especially for him the next time they met.